Liver Regeneration Following Radiofrequency Ablation

Background Radiofrequency ablation (RFA) of the liver leads to reduction of liver parenchymal volume. We sought to evaluate the regenerative response of the liver following RFA. Materials and Methods Thirty healthy New Zealand white rabbits were subjected to a single session liver RFA using a cool-t...

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Bibliographic Details
Published in:The Journal of surgical research 2008-11, Vol.150 (1), p.60-65
Main Authors: Ypsilantis, Petros, DVM, Ph.D, Pitiakoudis, Michail, M.D., Ph.D, Souftas, Vasilios D., M.D., Ph.D, Lambropoulou, Maria, M.D., Ph.D, Tsalikidis, Christos, M.D, Foutzitzi, Soultana, M.D, Tsigalou, Christina, M.D, Prassopoulos, Panagiotis, M.D., Ph.D, Papadopoulos, Nikolaos, M.D., Ph.D, Simopoulos, Constantinos, M.D., Ph.D
Format: Article
Language:English
Subjects:
ablation
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Biological and medical sciences
General aspects
Laparotomy
liver
Liver - diagnostic imaging
Liver - pathology
Liver Regeneration
Medical sciences
Mitotic Index
Other treatments
Rabbits
Radio Waves
radiofrequency
regeneration
Surgery
Tomography, X-Ray Computed
Treatment. General aspects
Tumors
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Summary:Background Radiofrequency ablation (RFA) of the liver leads to reduction of liver parenchymal volume. We sought to evaluate the regenerative response of the liver following RFA. Materials and Methods Thirty healthy New Zealand white rabbits were subjected to a single session liver RFA using a cool-tip electrode after midline laparotomy. The regenerative process of the liver was assessed at various time-points (0 h, 48 h, 1 wk, 3 wk, 10 wk) in terms of computed tomography-based liver volume measurements, histological examination, hepatocyte mitotic activity, and serum biochemistry. Results According to computed tomography-measurements, intact liver volume was gradually restored to the initial liver volume by the 10th week, while liver ablated volume was confined down to 50% of the initial ablated volume. At histology, inflammation, edema, and hepatocellular necrosis in the intact liver parenchyma, noted at 48 h, started to regress by 1 wk. Mitotic activity, initiated by 48 h, was substantially increased at 1 wk and remained high up to the 10th week. Serum transaminase levels were elevated up to 1 wk. Conclusions Liver RFA triggers a slow but sustained regenerative response of the liver with subsequent delayed restoration of parenchymal volume, while the ablated volume is gradually condensed.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2007.09.019