New tools for rapid clinical and bioagent diagnostics : microwaves and plasmonic nanostructures

In this timely review, we summarize recent work on ultra-fast and sensitive bioassays based on microwave heating, and provide our current interpretation of the role of the combined use of microwave energy and plasmonic nanostructures for applications in rapid clinical and bioagent diagnostics. The i...

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Bibliographic Details
Published in:Analyst (London) 2008-11, Vol.133 (11), p.1469-1480
Main Authors: ASIAN, Kadir, GEDDES, Chris D
Format: Article
Language:English
Subjects:
Analytical chemistry
Applied sciences
Chemistry
Enzyme-Linked Immunosorbent Assay - instrumentation
Enzyme-Linked Immunosorbent Assay - methods
Exact sciences and technology
Fluorescent Antibody Technique - instrumentation
Global environmental pollution
Humans
Luminescence
Microwaves
Nanostructures
Pollution
Proteins - analysis
Proteins - genetics
Quantum Dots
Spectrometry, Fluorescence - instrumentation
Spectrometry, Fluorescence - methods
Surface Plasmon Resonance - methods
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Summary:In this timely review, we summarize recent work on ultra-fast and sensitive bioassays based on microwave heating, and provide our current interpretation of the role of the combined use of microwave energy and plasmonic nanostructures for applications in rapid clinical and bioagent diagnostics. The incorporation of microwave heating into plasmonic nanostructure-based bioassays brings new advancements to diagnostic tests. A temperature gradient, created by the selective heating of water in the presence of plasmonic nanostructures, results in an increased mass transfer of target biomolecules towards the biorecognition partners placed on the plasmonic nanostructures, enabling diagnostic tests to be completed in less than a minute, and in some cases only a few seconds, by further microwave heating. The diagnostic tests can also be run in complex biological samples, such as human serum and whole blood.
ISSN:0003-2654
1364-5528
DOI:10.1039/b808292h