Protein folding as a nonlinear nonequilibrium thermodynamic process

Biofurcational theory of protein folding is developed describing the process of formation of protein native structure as a sequence of non‐equilibrium irreversible fluctuations, specific for a particular protein. The model gives explaination to all characteristic features of the folding process: sto...

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Bibliographic Details
Published in:Biochemistry and molecular biology international 1999-03, Vol.47 (3), p.443-453
Main Author: Popov, E. M.
Format: Article
Language:English
Subjects:
bifurcations
Entropy
nonlinear nonequilibrium thermodynamics
Oligopeptides - chemistry
Protein Conformation
protein conformational calculations
Protein Folding
Protein Structure, Tertiary
Proteins - chemistry
Thermodynamics
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Summary:Biofurcational theory of protein folding is developed describing the process of formation of protein native structure as a sequence of non‐equilibrium irreversible fluctuations, specific for a particular protein. The model gives explaination to all characteristic features of the folding process: stochastic mechanism, short time and precision of proteins self‐assembling. A constructiwe role of entropy in the formation of a highly ordered structure out of disorder is discussed. A numerical method of a priori calculations of polypeptide structures basing on principles of bifractional folding model is presented.
ISSN:1521-6543
1039-9712
1521-6551
DOI:10.1080/15216549900201473