The Role of Planar Scintimammography With High-Resolution Dedicated Breast Camera in the Diagnosis of Primary Breast Cancer

Planar scintimammography (SM) acquired with a conventional γ camera has proved a useful complementary tool to mammography (Mx) in breast cancer (BC) diagnosis, but with unsatisfactory sensitivity in small size carcinomas. In this study we assessed the role of planar SM with a high-resolution dedicat...

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Bibliographic Details
Published in:Clinical nuclear medicine 2008-11, Vol.33 (11), p.739-742
Main Authors: Spanu, Angela, Chessa, Francesca, Meloni, Giovanni Battista, Sanna, Daniela, Cottu, Pierina, Manca, Alessandra, Nuvoli, Susanna, Madeddu, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Female
Gamma Cameras
Humans
Mammography - instrumentation
Mammography - methods
Middle Aged
Organophosphorus Compounds
Organotechnetium Compounds
Radionuclide Imaging - instrumentation
Radiopharmaceuticals
Sensitivity and Specificity
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Summary:Planar scintimammography (SM) acquired with a conventional γ camera has proved a useful complementary tool to mammography (Mx) in breast cancer (BC) diagnosis, but with unsatisfactory sensitivity in small size carcinomas. In this study we assessed the role of planar SM with a high-resolution dedicated breast camera (DBC) in BC diagnosis, comparing the results with those of Mx.A consecutive series of 145 patients scheduled for biopsy for suspected BC underwent Tc-99m tetrofosmin planar SM using a newly developed DBC. Scintigraphic data were compared with Mx findings and correlated to histology.Histopathologic analysis revealed 165 lesions143 malignant and 22 benign. SM detected 139/143 carcinomas (overall sensitivity97.2%) and was true negative in 19/22 benign lesions (overall specificity86.4%). SM sensitivity was 91% in ≤10-mm carcinomas. SM was more accurate than Mx in 42/145 cases (29%), detecting cancer in 9 patients with Mx indeterminate for dense breasts (8/9 tumors were
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0b013e318187ee75