Biologic response to passive dissolution of titanium craniofacial microplates

• Published in: Biomaterials 1999-04, Vol.20 (7), p.675-682
• Main Authors: Jorgenson, Daniel S., Centeno, Jose A., Mayer, Michael H., Topper, Michael J., Nossov, Patricia C., Mullick, Florabel G., Manson, Paul N.
• Format: Article
• Language: English
• Subjects: Animals; Anodic oxidation; Biocompatibility; Biocompatible materials; Biological and medical sciences; Bone; Bone Plates; Cell Count; Dissolution; Electron probe microanalysis; Eosinophils - cytology; Facial Bones; Implants, Experimental; Leukocytes - cytology; Leukocytes - metabolism; Macrophages, Peritoneal - cytology; Male; Mast Cells - cytology; Medical sciences; Microanalysis; Peritoneal Cavity - cytology; Peritoneal Cavity - physiology; Physiological models; Proteins - metabolism; Rats; Rats, Sprague-Dawley; Spectrophotometry, Atomic - methods; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Tissue culture; Tissue Distribution; Titanium; Titanium - pharmacokinetics
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/S0142-9612(98)00225-7

The effect of anodization on passive dissolution of titanium was studied by measuring titanium levels in peritoneal leukocytes and tissues of laboratory animals with titanium plates implanted into the peritoneal cavity. Fifteen Sprague–Dawley rats were assigned randomly to three treatment groups of five animals. One group served as controls, the other two groups had an anodized or an unanodized implant placed in the left paracolic gutter. Peritoneal lavage samples and blood samples, organ tissues and tissue surrounding the implants, were removed for histologic examination and titanium levels. Titanium was not detected in any distant organs or in the peritoneal lavage fluid. The capsular tissues surrounding the implants contained titanium at levels ranging from 2610 to 16 786 ng/g for unanodized plates, and 888–5933 ng/g for anodized plates. The titanium levels within the peritoneal leukocytes of animals with unanodized implants were significantly elevated ( P=0.01) over time, as compared with controls. The level of titanium in the peritoneal leukocytes of animals with anodized implants was not significantly elevated when compared with controls. Titanium levels in the trace range, as measured in the capsular tissues, are likely a result of corrosion. Surface treatment of titanium by anodization reduces passive dissolution.