Applications of next-generation sequencing technologies in functional genomics

A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, t...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2008-11, Vol.92 (5), p.255-264
Main Authors: Morozova, Olena, Marra, Marco A.
Format: Article
Language:English
Subjects:
454/Roche
ABI/SOLiD
Biological and medical sciences
Biotechnology - methods
Computational Biology - methods
Deep sequencing
Epigenome
Functional genomics
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Genes. Genome
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
Genomics
Humans
Illumina/Solexa
Molecular and cellular biology
Molecular genetics
Next-generation sequencing technology
Sequence Analysis, DNA - instrumentation
Sequence Analysis, DNA - methods
Sequencing by ligation
Sequencing by synthesis
Transcriptome
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Summary:A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer.
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2008.07.001