Genetic Screening in Infertile Mexican Men: Chromosomal Abnormalities, Y Chromosome Deletions, and Androgen Receptor CAG Repeat Length

In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty‐two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome micro...

Full description

Saved in:
Bibliographic Details
Published in:Journal of andrology 2008-11, Vol.29 (6), p.654-660
Main Authors: Martinez-Garza, Sandra Guadalupe, Gallegos-Rivas, Mayra Celina, Vargas-Maciel, Marcos, Rubio-Rubio, Juan Manuel, de los Monteros-Rodriguez, Mario Espinosa, Gonzalez-Ortega, Claudia, Cancino-Villarreal, Patricia, de Lara, Luis G. Vazquez, Gutierrez-Gutierrez, Antonio Martin
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chromosome Aberrations
Chromosomes, Human, Y - genetics
Cytogenetic Analysis
Fundamental and applied biological sciences. Psychology
Genetic Testing
Gynecology. Andrology. Obstetrics
Humans
Infertility, Male - genetics
karyotype
Male
Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance
Male genital diseases
Mammalian male genital system
Medical sciences
Mexico
microdeletion
Oligospermia
Receptors, Androgen - genetics
trinucleotide repeat
Trinucleotide Repeat Expansion - genetics
Vertebrates: reproduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty‐two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y‐chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.
ISSN:0196-3635
1939-4640
DOI:10.2164/jandrol.107.004309