Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation

The rapid atrial rate during atrial fibrillation (AF) decreases the ionic current density of transient outward K+ current, L-type Ca2+ current, and Na+ current, thereby altering cardiac electrophysiology and promoting arrhythmia maintenance. To assess possible underlying changes in cardiac gene expr...

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Bibliographic Details
Published in:Circulation research 1999-04, Vol.84 (7), p.776-784
Main Authors: LIXIA YUE, MELNYK, P, GASPO, R, ZHIGUO WANG, NATTEL, S
Format: Article
Language:English
Subjects:
Animals
Antisense Elements (Genetics)
Atrial Fibrillation - physiopathology
Biological and medical sciences
Blotting, Western
Calcium Channels - analysis
Calcium Channels - genetics
Calcium Channels, L-Type
Cardiac dysrhythmias
Cardiology. Vascular system
Cloning, Molecular
Disease Models, Animal
DNA, Complementary
Dogs
Gene Expression - physiology
Heart
Medical sciences
Myocardium - chemistry
Potassium Channels - analysis
Potassium Channels - genetics
Potassium Channels, Inwardly Rectifying
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Sodium Channels - analysis
Sodium Channels - genetics
Transcription, Genetic - physiology
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Summary:The rapid atrial rate during atrial fibrillation (AF) decreases the ionic current density of transient outward K+ current, L-type Ca2+ current, and Na+ current, thereby altering cardiac electrophysiology and promoting arrhythmia maintenance. To assess possible underlying changes in cardiac gene expression, we applied competitive reverse transcriptase-polymerase chain reaction to quantify mRNA concentrations in dogs subjected to 7 (group P7 dogs) or 42 (group P42 dogs) days of atrial pacing at 400 bpm and in sham controls. Rapid pacing reduced mRNA concentrations of Kv4.3 (putative gene encoding transient outward K+ current; by 60% in P7 and 74% in P42 dogs; P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.84.7.776