Detection of hepatitis B surface antigen mutants and their integration in human hepatocellular carcinoma

Vaccine escape hepatitis B virus surface antigen (HBsAg) mutants are capable of independent replication and have been implicated in acute hepatitis. We now report the detection of these mutants with changes at various positions of the antigenic ‘a’ determinant in human hepatocellular carcinoma (HCC)...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 1999-02, Vol.136 (1), p.95-99
Main Authors: Oon, Chong Jin, Chen, Wei Ning, Zhao, Yi, Teng, Siaw Wei, Leong, Ai Lin
Format: Article
Language:English
Subjects:
Arginine
Biological and medical sciences
Blotting, Southern
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - virology
DNA, Neoplasm - chemistry
DNA, Neoplasm - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Glycine
Glycine-145-Arginine
Hepatitis B Surface Antigens - chemistry
Hepatitis B Surface Antigens - genetics
Hepatitis B Surface Antigens - isolation & purification
Hepatitis B virus surface mutant
Hepatocellular carcinoma
Humans
Integration
Liver Neoplasms - genetics
Liver Neoplasms - immunology
Liver Neoplasms - pathology
Liver Neoplasms - virology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Methionine
Methionine-133-Threonine
Mutation
Threonine
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vaccine escape hepatitis B virus surface antigen (HBsAg) mutants are capable of independent replication and have been implicated in acute hepatitis. We now report the detection of these mutants with changes at various positions of the antigenic ‘a’ determinant in human hepatocellular carcinoma (HCC). Southern blot analysis indicated that the HBsAg mutant with the Glycine to Arginine change at position 145 was integrated in HCC, whereas those with a Threonine at position 133 instead of a Methionine were identified in the serum of aggressive HCC. Further studies on HBsAg mutants in HCC should provide new insights on their involvement in the hepatocarcinogenesis.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(98)00314-0