Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides

The immunomodulating action of two mushroom antitumor polysaccharides, polysaccharide-protein complex (PSPC) and lentinan, was elucidated through analysing the expression profile of cytokines during a time course (0 h to 48 h) after their administration. Among the 5 cytokine genes, the induction of...

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Bibliographic Details
Published in:Life sciences (1973) 1999-02, Vol.64 (12), p.1005-1011
Main Authors: Liu, F., Ooi, V.E.C., Fung, M.C.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Agaricales - physiology
Animals
cytokine
Cytokines - genetics
immunomodulation
Interleukin-1 - genetics
Lentinan - pharmacology
Male
Mice
Mice, Inbred ICR
mushroom
polysaccharide
Polysaccharides - pharmacology
RNA, Messenger - analysis
splenocyte
Tumor Necrosis Factor-alpha - genetics
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Summary:The immunomodulating action of two mushroom antitumor polysaccharides, polysaccharide-protein complex (PSPC) and lentinan, was elucidated through analysing the expression profile of cytokines during a time course (0 h to 48 h) after their administration. Among the 5 cytokine genes, the induction of a marked increase in the mRNA levels of IL-1α, IL-1β, TNF-α, IFN-γ and M-CSF by PSPC and lentinan was observed in the peritoneal exudate cells and splenocytes. However, the time point of their increased production was different after PSPC and lentinan administration.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(99)00027-2