Involvement of capsaicin-sensitive sensory nerves in early and delayed cardioprotection induced by a brief ischaemia of the small intestine

Early cardioprotection can be achieved by a brief ischaemia of noncardiac tissues. Our study examined whether a brief ischaemia of the small intestine induces both early and delayed cardioprotection in the rabbit and assessed the possible mechanism involved in the activation of capsaicin-sensitive s...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1999-03, Vol.359 (3), p.243-247
Main Authors: Tang, Z L, Dai, W, Li, Y J, Deng, H W
Format: Article
Language:English
Subjects:
Animals
Calcitonin - immunology
Calcitonin Gene-Related Peptide - blood
Capsaicin - pharmacology
Creatine Kinase - blood
Female
Immunoassay
Intestine, Small - blood supply
Ischemic Preconditioning - methods
Male
Mesenteric Arteries - surgery
Myocardial Infarction - pathology
Neurons, Afferent - physiology
Rabbits
Reperfusion Injury - prevention & control
Time Factors
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Summary:Early cardioprotection can be achieved by a brief ischaemia of noncardiac tissues. Our study examined whether a brief ischaemia of the small intestine induces both early and delayed cardioprotection in the rabbit and assessed the possible mechanism involved in the activation of capsaicin-sensitive sensory nerves. The plasma concentration of creatine kinase (CK) and infarct size (necrotic zone/left ventricular zone) after 30 min coronary artery occlusion and 180 min reperfusion were determined in rabbits. Infarct size was 35.5+/-6.8% in the control non-preconditioned group. Preconditioning induced by a brief period of 10-min small intestine ischaemia significantly reduced infarct size (6.5+/-1.9%, P
ISSN:0028-1298
1432-1912
DOI:10.1007/PL00005348