Termination of DNA replication of bacterial and plasmid chromosomes

Sequence‐specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis‐acting ter site and a trans‐acting replication terminator protein. The interaction of a terminator protein with the ter site creates a protein–DNA complex that arrests replicati...

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Bibliographic Details
Published in:Molecular microbiology 1999-03, Vol.31 (6), p.1611-1618
Main Authors: Bussiere, Dirksen E., Bastia, Deepak
Format: Article
Language:English
Subjects:
Bacillus subtilis - genetics
Bacterial Proteins - genetics
Chromosomes, Bacterial - physiology
DNA Replication - physiology
DNA-Binding Proteins - genetics
Escherichia coli - genetics
Escherichia coli Proteins
Models, Genetic
Models, Molecular
Plasmids - physiology
Protein Structure, Secondary
R Factors - genetics
Terminator Regions, Genetic
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Summary:Sequence‐specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis‐acting ter site and a trans‐acting replication terminator protein. The interaction of a terminator protein with the ter site creates a protein–DNA complex that arrests replication forks in a polar fashion by antagonizing the action of the replicative helicase (thereby exhibiting a contrahelicase activity). Terminator proteins also arrest RNA polymerases in a polar fashion. Passage of an RNA transcript through a terminus from the non‐blocking direction abrogates replication termination function, a mechanism that is likely to be used in conditional termini or replication check points.
ISSN:0950-382X
1365-2958
DOI:10.1046/j.1365-2958.1999.01287.x