Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer

Numerous studies have linked cathepsins and their inhibitor cystatin C to tumor invasion and metastasis. We examined whether cathepsin B, cathepsin H, cathepsin X and cystatin C could be detected in sera from women with early stage or inflammatory breast cancer and whether they correlated with clini...

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Bibliographic Details
Published in:The International journal of biological markers 2008-07, Vol.23 (3), p.161-168
Main Authors: DECOCK, J, OBERMAJER, N, VOZELJ, S, HENDRICKX, W, PARIDAENS, R, KOS, J
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Breast Neoplasms - blood
Breast Neoplasms - pathology
Cathepsin B - blood
Cathepsin H
Cathepsin K
Cathepsins - blood
Cystatin C - blood
Cysteine Endopeptidases - blood
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Inflammation
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
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Summary:Numerous studies have linked cathepsins and their inhibitor cystatin C to tumor invasion and metastasis. We examined whether cathepsin B, cathepsin H, cathepsin X and cystatin C could be detected in sera from women with early stage or inflammatory breast cancer and whether they correlated with clinicopathological characteristics. Preoperative serum was obtained from 176 patients with early-stage breast cancer (tumor size
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080802300305