Prothrombin fragments F1+2, thrombin–antithrombin III complexes, fibrin monomers and fibrinogen in patients with coronary atherosclerosis

We determined the plasma levels of prothrombin fragment F1+2, thrombin–antithrombin III complexes (TAT), fibrin monomers (FM), d-dimers (DD) and fibrinogen in 57 patients with angiographically verified graded coronary artery disease (CAD) free of concomitant peripheral atherosclerosis, cerebrovascul...

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Bibliographic Details
Published in:International journal of cardiology 1999-03, Vol.68 (3), p.269-274
Main Authors: Giannitsis, Evangelos, Siemens, Hans J, Mitusch, Rolf, Tettenborn, Ivo, Wiegand, Uwe, Schmücker, Georg, Sheikhzadeh, Abdolhamid, Stierle, Ulrich
Format: Article
Language:English
Subjects:
Antithrombin III - analysis
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary heart disease
d-Dimer
Female
Fibrin Fibrinogen Degradation Products - analysis
Fibrin monomer
Fibrinogen
Fibrinogen - analysis
Heart
Hemostasis - physiology
Humans
Male
Medical sciences
Middle Aged
Peptide Fragments - analysis
Peptide Hydrolases - analysis
Prothrombin - analysis
Prothrombin fragments
Thrombin–antithrombin III complex
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Summary:We determined the plasma levels of prothrombin fragment F1+2, thrombin–antithrombin III complexes (TAT), fibrin monomers (FM), d-dimers (DD) and fibrinogen in 57 patients with angiographically verified graded coronary artery disease (CAD) free of concomitant peripheral atherosclerosis, cerebrovascular disease or diabetes mellitus and a group of 21 apparently healthy controls. Blood was collected from the antecubital vein through atraumatic venipuncture prior to the angiographic procedure. Plasma levels of hemostatic markers were related to the presence and graded severity of CAD. The levels of prothrombin fragment F1+2 (1.74±0.11 vs. 1.0±0.07 nmol/l, P
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(98)00256-3