The effects of reformulation: Improved therapeutic index

Antimuscarinic agents are the treatment of choice for overactive bladder syndrome. Due to the development of novel delivery systems, extended-release formulations of oxybutynin, tolterodine, and trospium chloride are now available. In addition to the convenience of once-daily dosing, the new formula...

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Bibliographic Details
Published in:Current urology reports 2008-11, Vol.9 (6), p.465-471, Article 465
Main Authors: MacDiarmid, Scott, Sandage, Bobby W., Malhotra, Bimal K.
Format: Article
Language:English
Subjects:
Benzhydryl Compounds - therapeutic use
Benzilates
Chemistry, Pharmaceutical
Cresols - therapeutic use
Humans
Mandelic Acids - therapeutic use
Medicine
Medicine & Public Health
Muscarinic Antagonists - therapeutic use
Nephrology
Nortropanes - therapeutic use
Phenylpropanolamine - therapeutic use
Tolterodine Tartrate
Urinary Bladder, Overactive - drug therapy
Urology
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Summary:Antimuscarinic agents are the treatment of choice for overactive bladder syndrome. Due to the development of novel delivery systems, extended-release formulations of oxybutynin, tolterodine, and trospium chloride are now available. In addition to the convenience of once-daily dosing, the new formulations of these commonly prescribed agents have improved their therapeutic index, striking a better balance between efficacy and tolerability.
ISSN:1527-2737
1534-6285
DOI:10.1007/s11934-008-0080-6