The putative gene for the first enzyme of glutathione biosynthesis in Plasmodium berghei and Plasmodium falciparum

The putative gene for γ-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis, has been characterized both in Plasmodium berghei and Plasmodium falciparum. Protein sequence comparison between these two species reveals large conserved regions sharing more than 80% similari...

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Bibliographic Details
Published in:Molecular and biochemical parasitology 1999-03, Vol.99 (1), p.33-40
Main Authors: Birago, Cecilia, Pace, Tomasino, Picci, Leonardo, Pizzi, Elisabetta, Scotti, Raffaella, Ponzi, Marta
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Fluorescent Antibody Technique
Genes, Protozoan
Glutamate-Cysteine Ligase - chemistry
Glutamate-Cysteine Ligase - genetics
Glutamate-Cysteine Ligase - metabolism
Glutathione - biosynthesis
Humans
Mice
Molecular Sequence Data
Plasmodium
Plasmodium berghei
Plasmodium berghei - enzymology
Plasmodium berghei - genetics
Plasmodium falciparum
Plasmodium falciparum - enzymology
Plasmodium falciparum - genetics
Rats
Rats, Wistar
Sequence Analysis, DNA
Transcription, Genetic
γ-Glutamylcysteine synthetase
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Summary:The putative gene for γ-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis, has been characterized both in Plasmodium berghei and Plasmodium falciparum. Protein sequence comparison between these two species reveals large conserved regions sharing more than 80% similarity, separated by less conserved portions. When the comparison is extended to known γ-glutamylcysteine synthetases from other eukaryotes, a number of high similarity blocks are observed which may help in identifying sequence essential for protein function.
ISSN:0166-6851
1872-9428
DOI:10.1016/S0166-6851(98)00179-0