Expression of periostin in patients with non-small cell lung cancer : correlation with angiogenesis and lymphangiogenesis

The aim of this study was to evaluate periostin expression measured immunohistochemically in patients with non-small cell lung cancer (NSCLC) and to determine its association with clinical features, prognosis, angiogenesis, and lymphangiogenesis. We investigated periostin expression in a series of 8...

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Bibliographic Details
Published in:The International journal of biological markers 2008-07, Vol.23 (3), p.182-186
Main Authors: TAKANAMI, I, ABIKO, T, KOIZUMI, S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - metabolism
Cell Adhesion Molecules - biosynthesis
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry - methods
Investigative techniques, diagnostic techniques (general aspects)
Lung Neoplasms - metabolism
Lymphangiogenesis
Male
Medical sciences
Middle Aged
Neovascularization, Pathologic
Treatment Outcome
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Summary:The aim of this study was to evaluate periostin expression measured immunohistochemically in patients with non-small cell lung cancer (NSCLC) and to determine its association with clinical features, prognosis, angiogenesis, and lymphangiogenesis. We investigated periostin expression in a series of 88 patients with NSCLC. We also determined whether expression of periostin correlated with microvessel density and lymphatic microvessel density. Periostin was expressed in 42% of 88 patients. Its expression was significantly correlated with tumor size, lymph node metastasis, disease stage, and lymphatic invasion (p=0.0128, 0.0015, 0.0310 and 0.0273, respectively). There also was a significant relation between periostin expression and microvessel density and lymphatic microvessel density (all p
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080802300308