Serum N-3 Polyunsaturated Fatty Acid Levels Correlate With the Extent of Coronary Plaques and Calcifications in Patients With Acute Myocardial Infarction

Background The relationship between serum fatty acid levels and the extent of coronary plaques and calcification was examined in patients with acute myocardial infarction (AMI). Methods and Results The serum levels of the n-3 polyunsaturated fatty acids (eicosapentaenoic acid (EPA) and docosahexaeno...

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Bibliographic Details
Published in:Circulation Journal 2008, Vol.72(11), pp.1836-1843
Main Authors: Ueeda, Masayuki, Doumei, Takenori, Takaya, Yoichi, Shinohata, Ryoko, Katayama, Yusuke, Ohnishi, Nobuhiko, Takaishi, Atsushi, Miyoshi, Toru, Hirohata, Satoshi, Kusachi, Shozo
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Calcinosis - blood
Calcinosis - diagnostic imaging
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Vessels - metabolism
Fatty acids
Fatty Acids, Unsaturated - blood
Female
Humans
Infarction
Male
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - diagnostic imaging
Risk factors
Tomography, X-Ray Computed
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Summary:Background The relationship between serum fatty acid levels and the extent of coronary plaques and calcification was examined in patients with acute myocardial infarction (AMI). Methods and Results The serum levels of the n-3 polyunsaturated fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and the n-6 polyunsaturated fatty acids (arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA)) were determined using gas chromatography on admission of 95 consecutive patients with their first AMI and 17 controls. Using multidetector-row computed tomography, soft plaques and calcification lesions were scored according to the extent of coronary involvement. Serum logarithmic transformed (log) EPA and logDHA levels were inversely correlated with soft plaque scores (r=-0.546, p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-0249