Endoscopic Sinus Surgery Improves Pulmonary Function in Patients with Asthma Associated with Chronic Sinusitis

• Published in: Annals of otology, rhinology & laryngology rhinology & laryngology, 1999-04, Vol.108 (4), p.355-359
• Main Authors: Ikeda, Katsuhisa, Tamura, Gen, Shimomura, Akira, Suzuki, Hideaki, Nakabayashi, Seiichiro, Tanno, Noriko, Oshima, Takeshi, Takasaka, Tomonori
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anti-Inflammatory Agents - therapeutic use; Asthma - etiology; Biological and medical sciences; Chronic Disease; Dexamethasone - therapeutic use; Dose-Response Relationship, Drug; Endoscopy - methods; Female; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Humans; Lung - physiopathology; Male; Medical sciences; Middle Aged; Paranasal Sinuses - diagnostic imaging; Postoperative Care; Preoperative Care; Respiratory Function Tests; Retrospective Studies; Sinusitis - complications; Sinusitis - diagnosis; Sinusitis - drug therapy; Sinusitis - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the upper aerodigestive tract; Surveys and Questionnaires; Tomography, X-Ray Computed; Treatment Outcome
• ISSN: 0003-4894; 1943-572X
• DOI: 10.1177/000348949910800407

We evaluated the clinical efficacy of endonasal endoscopic sinus surgery (ESS) in patients with asthma associated with chronic sinusitis. Twenty-one patients (13 men and 8 women) from 27 to 72 years old were enrolled in this study. All patients had had sinus-related symptoms for more than 3 months and had computed tomographic evidence of paranasal sinus opacification. Fifteen patients underwent bilateral endonasal ESS under local anesthesia, and 6 other patients without surgery were controls. The sinus-related symptoms of the preoperative and postoperative periods were assessed via a questionnaire. The period 6 months prior to surgery was compared with that 6 months postoperatively with regard to peak expiratory flow and total dosage of systemic glucocorticoids. Sinus-related symptoms in the ESS group were significantly improved 6 months postoperatively. The average peak expiratory flow 6 months following surgery was improved in the ESS patients, ranging from 40 to 190 L/min. Seven patients showed a reduction in the need for corticosteroids, whereas 2 patients were unchanged and 2 patients required larger dosages. The remaining 4 patients needed no corticosteroids before or after ESS. No significant changes in sinus-related symptoms or peak expiratory flow were obtained for the control group. Improvement of paranasal sinus disease by successful ESS can alleviate pulmonary dysfunction in asthma associated with chronic sinusitis. We believe that adequate and positive treatment for chronic sinusitis would reduce not only the nasal and sinus-related symptoms evoked by chronic sinusitis, but also some of the signs induced by asthma.