Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein

We have previously reported that Aleuria aurantia lectin (AAL)-reactive serum cholinesterase (ChE) activity increases in liver cirrhosis (LC) and hepatocellular carcinoma (HCC) compared with chronic hepatitis (CH) and normal controls (NC), and measurement of AAL-reactive ChE activity is useful in di...

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Bibliographic Details
Published in:Clinica chimica acta 1999-03, Vol.281 (1), p.37-46
Main Authors: Hada, Toshikazu, Kondo, Masahide, Yasukawa, Kiyoshi, Amuro, Yoshiki, Higashino, Kazuya
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cholinesterases - blood
Cholinesterases - metabolism
Chronic liver disease
Diagnosis, Differential
Digestive system
ELISA
Enzyme-Linked Immunosorbent Assay
Hepatitis, Chronic - diagnosis
Hepatitis, Viral, Human - diagnosis
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lectin
Lectins - metabolism
Liver Cirrhosis - diagnosis
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Sensitivity and Specificity
Sugar chain
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Summary:We have previously reported that Aleuria aurantia lectin (AAL)-reactive serum cholinesterase (ChE) activity increases in liver cirrhosis (LC) and hepatocellular carcinoma (HCC) compared with chronic hepatitis (CH) and normal controls (NC), and measurement of AAL-reactive ChE activity is useful in discriminating LC from CH. In the present study, we have demonstrated that the measurement of the ratio of AAL-reactive ChE to immuno-reactive ChE protein (AAL/ChE) is superior to the measurement of only AAL-reactive ChE for differentiating LC from CH. At a cut-off value of 4.0 arbitrary units of AAL/ChE, the diagnostic accuracy was 87.7%. This diagnostic accuracy is similar to that of serum hyaluronan, 88.8%. We also examined whether the AAL/ChE measurement is useful for differentiating Child's stage A LC from chronic active hepatitis (CAH) 2B. When mean+2SD of AAL/ChE in patients with CAH2B was used as a cut-off value for the specific diagnosis of LC, the diagnostic accuracy was 70.2%. These results demonstrate that measurement of AAL/ChE is useful for discriminating LC from CH.
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(98)00202-2