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Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats

gamma-aminobutyric acid (GABA)-containing fibers from the nucleus accumbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to the lateral hypothalamus (LH). Therefore, the VPm is anatomically interposed between the AcbSh and LH, two functionally related b...

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Bibliographic Details
Published in:Brain research 1999-04, Vol.825 (1-2), p.199-203
Main Authors: STRATFORD, T. R, KELLEY, A. E, SIMANSKY, K. J
Format: Article
Language:English
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Summary:gamma-aminobutyric acid (GABA)-containing fibers from the nucleus accumbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to the lateral hypothalamus (LH). Therefore, the VPm is anatomically interposed between the AcbSh and LH, two functionally related brain regions that mediate food intake. The present study demonstrates that blockade of GABAA receptors in the VPm by local administration of bicuculline greatly increases food intake in satiated rats. The data suggest that an AcbSh-VPm-LH circuit may be involved in the control of feeding behavior.
ISSN:0006-8993
1872-6240
DOI:10.1016/s0006-8993(99)01239-1