The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury

The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in re...

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Bibliographic Details
Published in:Neuropharmacology 1999-02, Vol.38 (2), p.319-321
Main Authors: SCHRÖDER, U. H, BREDER, J, SABELHAUS, C. F, REYMANN, K. G
Format: Article
Language:English
Subjects:
Animals
Biochemistry and metabolism
Biological and medical sciences
Cell Hypoxia
Central nervous system
Fundamental and applied biological sciences. Psychology
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - physiology
Hypoglycemia
In Vitro Techniques
Male
Medical sciences
Membrane Potentials - drug effects
Neurons - cytology
Neurons - drug effects
Neurons - physiology
Neuropharmacology
Neuroprotective agent
Neuroprotective Agents - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Wistar
Sodium-Calcium Exchanger - antagonists & inhibitors
Thiourea - analogs & derivatives
Thiourea - pharmacology
Vertebrates: nervous system and sense organs
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Summary:The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons.
ISSN:0028-3908
1873-7064
DOI:10.1016/s0028-3908(98)00198-1