Intrastriatal injection of hypoxanthine impairs memory formation of step-down inhibitory avoidance task in rats

The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine, the major compound accumulated in Lesch–Nyhan disease, on performance step-down inhibitory avoidance task in the rat. Male adult Wistar rats were divided in two groups: (1) saline-injected and (2) hypoxa...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2008-10, Vol.90 (4), p.594-597
Main Authors: Bavaresco, Caren Serra, Ben, Juliana, Chiarani, Fabria, Netto, Carlos Alexandre, de Souza Wyse, Angela Terezinha
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
Basal Ganglia - physiology
Biological and medical sciences
Hypoxanthine - administration & dosage
Hypoxanthine - pharmacology
Intrastriatal hypoxanthine administration
Lesch–Nyhan disease
Male
Medical sciences
Memory
Memory - drug effects
Microinjections
Neostriatum
Rats
Rats, Wistar
Step-down inhibitory avoidance task
Stereotaxic Techniques
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Summary:The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine, the major compound accumulated in Lesch–Nyhan disease, on performance step-down inhibitory avoidance task in the rat. Male adult Wistar rats were divided in two groups: (1) saline-injected and (2) hypoxanthine-injected group. Treated-group received intrastriatal hypoxanthine solution 30min before training session (memory acquisition) or immediately after training session (memory consolidation) or 30 before test session (memory retrieval) on step-down inhibitory avoidance task. Results show that hypoxanthine administration caused significant memory impairment in all periods tested. These results show that intrastriatal hypoxanthine administration provoked memory process impairment of step-down inhibitory avoidance task, an effect that might be related to the cognitive memory alterations in Lesch–Nyhan patients.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2008.05.001