T(peak)T(end) interval in long QT syndrome

The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occur...

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Bibliographic Details
Published in:Journal of electrocardiology 2008-11, Vol.41 (6), p.603-608
Main Authors: Kanters, Jorgen K, Haarmark, Christian, Vedel-Larsen, Esben, Andersen, Mads P, Graff, Claus, Struijk, Johannes J, Thomsen, Poul Erik Bloch, Christiansen, Michael, Jensen, Henrik K, Toft, Egon
Format: Article
Language:English
Subjects:
Adult
Comorbidity
Denmark - epidemiology
Diagnosis, Computer-Assisted - methods
Electrocardiography - methods
Electrocardiography - statistics & numerical data
Female
Humans
Incidence
Long QT Syndrome - diagnosis
Long QT Syndrome - epidemiology
Male
Reproducibility of Results
Risk Assessment - methods
Risk Factors
Sensitivity and Specificity
Syncope - diagnosis
Syncope - epidemiology
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Summary:The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope. Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval. (1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.
ISSN:1532-8430
DOI:10.1016/j.jelectrocard.2008.07.024