Physiological basis for potassium (39K) magnetic resonance imaging of the heart

The potassium cation (K+) is fundamentally involved in myocyte metabolism. To explore the potential utility of direct MRI of the most abundant natural isotope of potassium, 39K, we compared 39K magnetic resonance (MR) image intensity with regional myocardial K+ concentrations after irreversible inju...

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Bibliographic Details
Published in:Circulation research 1999-04, Vol.84 (8), p.913-920
Main Authors: FIENO, D. S, KIM, R. J, REHWALD, W. G, JUDD, R. M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiovascular system
Coronary Disease - diagnosis
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Medical sciences
Myocardium - chemistry
Myocardium - pathology
Potassium - analysis
Rabbits
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:The potassium cation (K+) is fundamentally involved in myocyte metabolism. To explore the potential utility of direct MRI of the most abundant natural isotope of potassium, 39K, we compared 39K magnetic resonance (MR) image intensity with regional myocardial K+ concentrations after irreversible injury. Rabbits were subjected either to 40 minutes of in situ coronary artery occlusion and 1 hour of reperfusion (n=26) or to 24 hours of permanent occlusion (n=4). The hearts were then isolated and imaged by 39K MRI (n=10), or tissue samples were analyzed for regional 39K content by MR spectroscopy (n=9), K+ and Na+ concentrations by atomic emission spectroscopy (inductively coupled plasma atomic emission spectroscopy; n=5), or intracellular K+ content by electron probe x-ray microanalysis (n=6). Three-dimensional 39K MR images of the isolated hearts were acquired in 44 minutes with 3 x 3 x 3-mm resolution. 39K MR image intensity was reduced in infarcted regions (51.7+/-4. 8% of remote; P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.84.8.913