Long-term follow-up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy

• Published in: European journal of haematology 1999-04, Vol.62 (4), p.219-222
• Main Authors: Mazzucconi, Maria Gabriella, Arista, Maria Cristina, Peraino, Monica, Chistolini, Antonio, Felici, Carla, Francavilla, Vittorio, Macale, Elvira, Conti, Laura, Gandolfo, Giuseppe Maria
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; autoimmune thrombocytopenic purpura; Biological and medical sciences; Blood Platelets - immunology; Disease-Free Survival; Female; Follow-Up Studies; Hematologic and hematopoietic diseases; Humans; Immunoglobulin G - blood; Male; Medical sciences; Middle Aged; Platelet diseases and coagulopathies; Prednisone - therapeutic use; Purpura, Thrombocytopenic, Idiopathic - blood; Purpura, Thrombocytopenic, Idiopathic - immunology; Purpura, Thrombocytopenic, Idiopathic - surgery; Splenectomy; Time Factors
• ISSN: 0902-4441; 1600-0609
• DOI: 10.1111/j.1600-0609.1999.tb01750.x

:  We studied the general outcome in 94 adult patients with autoimmune thrombocytopenic purpura (ATP) submitted to splenectomy. Of 84/94 patients who presented a complete or partial response 30 d after splenectomy, 16 (19%) showed one or more relapses. The clinical situation of the 81 patients still under observation is as follows: 13 unrensponsive, 60 completely or partially responsive, without relapses during the follow‐up, 8 completely or partially responsive after one or more relapses. No correlation was found between the favourable splenectomy outcome and age at splenectomy, the diagnosis‐splenectomy interval and initial response to corticosteroids. The probability of disease‐free survival is 83%, projected at 10 yr, while the overall survival is 93%, projected at 10 yr. PAIgG levels of the normal subjects and of responding patients were found to be similar, while in the groups of non‐responding/relapsing patients, significantly higher values of PAIgG were detected, as compared to the control group.