Seroprevalence and anti-HEV persistence in the general population of the Republic of San Marino

The prevalence of anti‐HEV was assessed in 2,233 subjects aged 20–79 years in the Republic of San Marino in the years 1990–1991. The sera were tested by ELISA and further confirmed by Western blot (WB) analysis. The overall anti‐HEV prevalence was 1.5%. A significant trend by age was observed. Anti‐...

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Published in:Journal of medical virology 1999-05, Vol.58 (1), p.49-53
Main Authors: Rapicetta, Maria, Kondili, Loreta Anesti, Pretolani, Stefano, Stroffolini, Tommaso, Chionne, Paola, Villano, Umbertina, Madonna, Elisabetta, Casali, Ferruccio, Gasbarrini, Giovanni
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Epidemiology
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
hepatitis E
Hepatitis E - blood
Hepatitis E - epidemiology
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus
Hepatitis E virus - immunology
HEV antibody
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Prevalence
San Marino - epidemiology
Viral diseases
Viral hepatitis
Virology
Western blot
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container_issue 1
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container_title Journal of medical virology
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creator Rapicetta, Maria
Kondili, Loreta Anesti
Pretolani, Stefano
Stroffolini, Tommaso
Chionne, Paola
Villano, Umbertina
Madonna, Elisabetta
Casali, Ferruccio
Gasbarrini, Giovanni
description The prevalence of anti‐HEV was assessed in 2,233 subjects aged 20–79 years in the Republic of San Marino in the years 1990–1991. The sera were tested by ELISA and further confirmed by Western blot (WB) analysis. The overall anti‐HEV prevalence was 1.5%. A significant trend by age was observed. Anti‐HEV prevalence was 0.6% in subjects
doi_str_mv 10.1002/(SICI)1096-9071(199905)58:1<49::AID-JMV7>3.0.CO;2-C
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The sera were tested by ELISA and further confirmed by Western blot (WB) analysis. The overall anti‐HEV prevalence was 1.5%. A significant trend by age was observed. Anti‐HEV prevalence was 0.6% in subjects &lt;30 years and 3.3% in those older than 70 years of age. Family size larger than four persons (OR = 3.8; 95% CI = 1.8–13.2) was the sole independent predictor of anti‐HEV positivity in the multivariate analysis. Anti‐HAV and anti‐HEV prevalences did not show a parallel trend by age. No association was found either between hepatitis E virus (HEV) or hepatitis C virus (HCV) infections. Follow‐up samples 5 years apart were available for 38 out of 54 (70%) anti‐HEV ELISA‐positive subjects. Eight out of 22 (37%) WB‐confirmed anti‐HEV–positive subjects were still anti‐HEV–positive after 5 years. However, anti‐HEV remained positive in all but two (75%) of the subjects with WB‐confirmed ELISA positivity value of S/CO ≥ 2 (cutoff 1.2), but in only 2 out of the 14 subjects (14%) with a WB‐con‐ firmed ELISA positivity value of S/CO &lt; 2 (P &lt; 0.005). None of the 16 subjects ELISA‐positive but not WB‐confirmed was anti‐HEV–positive 5 years apart. Therefore, only a relative proportion of subjects once infected with HEV maintain for at least 5 years anti‐HEV antibodies. J. Med. Virol. 58:49–53, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/(SICI)1096-9071(199905)58:1&lt;49::AID-JMV7&gt;3.0.CO;2-C</identifier><identifier>PMID: 10223545</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>New York: John Wiley &amp; Sons, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Epidemiology ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. 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Med. Virol</addtitle><description>The prevalence of anti‐HEV was assessed in 2,233 subjects aged 20–79 years in the Republic of San Marino in the years 1990–1991. The sera were tested by ELISA and further confirmed by Western blot (WB) analysis. The overall anti‐HEV prevalence was 1.5%. A significant trend by age was observed. Anti‐HEV prevalence was 0.6% in subjects &lt;30 years and 3.3% in those older than 70 years of age. Family size larger than four persons (OR = 3.8; 95% CI = 1.8–13.2) was the sole independent predictor of anti‐HEV positivity in the multivariate analysis. Anti‐HAV and anti‐HEV prevalences did not show a parallel trend by age. No association was found either between hepatitis E virus (HEV) or hepatitis C virus (HCV) infections. Follow‐up samples 5 years apart were available for 38 out of 54 (70%) anti‐HEV ELISA‐positive subjects. Eight out of 22 (37%) WB‐confirmed anti‐HEV–positive subjects were still anti‐HEV–positive after 5 years. 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subjects Adult
Aged
Biological and medical sciences
Epidemiology
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
hepatitis E
Hepatitis E - blood
Hepatitis E - epidemiology
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus
Hepatitis E virus - immunology
HEV antibody
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Prevalence
San Marino - epidemiology
Viral diseases
Viral hepatitis
Virology
Western blot
title Seroprevalence and anti-HEV persistence in the general population of the Republic of San Marino
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