Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat

• Published in: Fundamental & clinical pharmacology 1999-01, Vol.13 (2), p.226-231
• Main Authors: Monneret, Guillaume, Sassard, Jean, Benzoni, Daniel
• Format: Article
• Language: English
• Subjects: Animals; Arachidonic Acid - metabolism; Biological and medical sciences; Cyclic GMP - metabolism; Cytochrome P-450 Enzyme System - metabolism; cytochrome P450; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Hypertension - enzymology; Hypertension - genetics; hypertensive rat; In Vitro Techniques; kidney; Kidney - drug effects; Kidney - enzymology; Kidney - metabolism; Kidney Function Tests; Male; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Prostaglandins F - metabolism; Rats; Renal Circulation - physiology; Renovascular diseases; Sodium - metabolism; Thromboxane B2 - metabolism
• ISSN: 0767-3981; 1472-8206
• DOI: 10.1111/j.1472-8206.1999.tb00343.x

— This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single‐pass perfused at different pressure levels before (control conditions) and after cytochrome P450 inhibition by 7‐ethoxyresorufin (7‐ER, 1 μM). In control conditions, LH kidneys differed from LN ones by an increased preglomerular resistance and a blunted pressure natriuresis. 7‐ER, which did not affect the function of LN kidneys, decreased the vascular resistance of LH kidneys, increased their glomerular filtration rate but had no effect on their pressure natriuresis. These results indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional alterations exhibited by LH kidneys.