Loading…
Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat
— This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single‐pass perfused at different press...
Saved in:
| Published in: | Fundamental & clinical pharmacology 1999-01, Vol.13 (2), p.226-231 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033 |
| container_end_page | 231 |
| container_issue | 2 |
| container_start_page | 226 |
| container_title | Fundamental & clinical pharmacology |
| container_volume | 13 |
| creator | Monneret, Guillaume Sassard, Jean Benzoni, Daniel |
| description | — This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single‐pass perfused at different pressure levels before (control conditions) and after cytochrome P450 inhibition by 7‐ethoxyresorufin (7‐ER, 1 μM). In control conditions, LH kidneys differed from LN ones by an increased preglomerular resistance and a blunted pressure natriuresis. 7‐ER, which did not affect the function of LN kidneys, decreased the vascular resistance of LH kidneys, increased their glomerular filtration rate but had no effect on their pressure natriuresis. These results indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional alterations exhibited by LH kidneys. |
| doi_str_mv | 10.1111/j.1472-8206.1999.tb00343.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69726550</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69726550</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033</originalsourceid><addsrcrecordid>eNqVkF1rFDEUhoNY7Fr9CxJEvJtpPibJxAtBF7sKixapFHoTkswZNuvszDbJ6u6_d5ZZam-bmwTyvO85PAi9paSk47lcl7RSrKgZkSXVWpfZEcIrXu6fodnD13M0I0qqguuanqOXKa0JoYpQ-QKdU8KYVLKeoeVP6G2HoW3B54SHFvvrShBso_Wr0Ay9zYA3kK0bupAh4dDjvAK8PAw9Xh22EDP0KfwBHG1-hc5a2yV4fbov0K-rLzfzr8Xyx-Lb_NOy8BVXvKgdA62FYFJqzXjDLXOsVjVXkhOhWuErUnPBbeWYk1VTOSuc9bypbetbwvkFej_1buNwv4OUzSYkD11nexh2yUitmBSCjOCHCfRxSClCa7YxbGw8GErM0aVZm6MwcxRmji7NyaXZj-E3pyk7t4HmUXSSNwLvToBN3nZttL0P6T-nKFdEjdjHCfsbOjg8YQNzNb8eH2NBMRWElGH_UGDjbyMVV8Lcfl-Yz3dc36jbhbnj_wAyRZ6i</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69726550</pqid></control><display><type>article</type><title>Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Monneret, Guillaume ; Sassard, Jean ; Benzoni, Daniel</creator><creatorcontrib>Monneret, Guillaume ; Sassard, Jean ; Benzoni, Daniel</creatorcontrib><description>— This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single‐pass perfused at different pressure levels before (control conditions) and after cytochrome P450 inhibition by 7‐ethoxyresorufin (7‐ER, 1 μM). In control conditions, LH kidneys differed from LN ones by an increased preglomerular resistance and a blunted pressure natriuresis. 7‐ER, which did not affect the function of LN kidneys, decreased the vascular resistance of LH kidneys, increased their glomerular filtration rate but had no effect on their pressure natriuresis. These results indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional alterations exhibited by LH kidneys.</description><identifier>ISSN: 0767-3981</identifier><identifier>EISSN: 1472-8206</identifier><identifier>DOI: 10.1111/j.1472-8206.1999.tb00343.x</identifier><identifier>PMID: 10226768</identifier><identifier>CODEN: FCPHEZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Arachidonic Acid - metabolism ; Biological and medical sciences ; Cyclic GMP - metabolism ; Cytochrome P-450 Enzyme System - metabolism ; cytochrome P450 ; Dose-Response Relationship, Drug ; Glomerular Filtration Rate ; Hypertension - enzymology ; Hypertension - genetics ; hypertensive rat ; In Vitro Techniques ; kidney ; Kidney - drug effects ; Kidney - enzymology ; Kidney - metabolism ; Kidney Function Tests ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Prostaglandins F - metabolism ; Rats ; Renal Circulation - physiology ; Renovascular diseases ; Sodium - metabolism ; Thromboxane B2 - metabolism</subject><ispartof>Fundamental & clinical pharmacology, 1999-01, Vol.13 (2), p.226-231</ispartof><rights>1999 Société Française de Pharmacologie et de Thérapeutique</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033</citedby><cites>FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1713707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10226768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monneret, Guillaume</creatorcontrib><creatorcontrib>Sassard, Jean</creatorcontrib><creatorcontrib>Benzoni, Daniel</creatorcontrib><title>Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat</title><title>Fundamental & clinical pharmacology</title><addtitle>Fundam Clin Pharmacol</addtitle><description>— This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single‐pass perfused at different pressure levels before (control conditions) and after cytochrome P450 inhibition by 7‐ethoxyresorufin (7‐ER, 1 μM). In control conditions, LH kidneys differed from LN ones by an increased preglomerular resistance and a blunted pressure natriuresis. 7‐ER, which did not affect the function of LN kidneys, decreased the vascular resistance of LH kidneys, increased their glomerular filtration rate but had no effect on their pressure natriuresis. These results indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional alterations exhibited by LH kidneys.</description><subject>Animals</subject><subject>Arachidonic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cyclic GMP - metabolism</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>cytochrome P450</subject><subject>Dose-Response Relationship, Drug</subject><subject>Glomerular Filtration Rate</subject><subject>Hypertension - enzymology</subject><subject>Hypertension - genetics</subject><subject>hypertensive rat</subject><subject>In Vitro Techniques</subject><subject>kidney</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>Kidney - metabolism</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Prostaglandins F - metabolism</subject><subject>Rats</subject><subject>Renal Circulation - physiology</subject><subject>Renovascular diseases</subject><subject>Sodium - metabolism</subject><subject>Thromboxane B2 - metabolism</subject><issn>0767-3981</issn><issn>1472-8206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqVkF1rFDEUhoNY7Fr9CxJEvJtpPibJxAtBF7sKixapFHoTkswZNuvszDbJ6u6_d5ZZam-bmwTyvO85PAi9paSk47lcl7RSrKgZkSXVWpfZEcIrXu6fodnD13M0I0qqguuanqOXKa0JoYpQ-QKdU8KYVLKeoeVP6G2HoW3B54SHFvvrShBso_Wr0Ay9zYA3kK0bupAh4dDjvAK8PAw9Xh22EDP0KfwBHG1-hc5a2yV4fbov0K-rLzfzr8Xyx-Lb_NOy8BVXvKgdA62FYFJqzXjDLXOsVjVXkhOhWuErUnPBbeWYk1VTOSuc9bypbetbwvkFej_1buNwv4OUzSYkD11nexh2yUitmBSCjOCHCfRxSClCa7YxbGw8GErM0aVZm6MwcxRmji7NyaXZj-E3pyk7t4HmUXSSNwLvToBN3nZttL0P6T-nKFdEjdjHCfsbOjg8YQNzNb8eH2NBMRWElGH_UGDjbyMVV8Lcfl-Yz3dc36jbhbnj_wAyRZ6i</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Monneret, Guillaume</creator><creator>Sassard, Jean</creator><creator>Benzoni, Daniel</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat</title><author>Monneret, Guillaume ; Sassard, Jean ; Benzoni, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Arachidonic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cyclic GMP - metabolism</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>cytochrome P450</topic><topic>Dose-Response Relationship, Drug</topic><topic>Glomerular Filtration Rate</topic><topic>Hypertension - enzymology</topic><topic>Hypertension - genetics</topic><topic>hypertensive rat</topic><topic>In Vitro Techniques</topic><topic>kidney</topic><topic>Kidney - drug effects</topic><topic>Kidney - enzymology</topic><topic>Kidney - metabolism</topic><topic>Kidney Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Prostaglandins F - metabolism</topic><topic>Rats</topic><topic>Renal Circulation - physiology</topic><topic>Renovascular diseases</topic><topic>Sodium - metabolism</topic><topic>Thromboxane B2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monneret, Guillaume</creatorcontrib><creatorcontrib>Sassard, Jean</creatorcontrib><creatorcontrib>Benzoni, Daniel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fundamental & clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monneret, Guillaume</au><au>Sassard, Jean</au><au>Benzoni, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat</atitle><jtitle>Fundamental & clinical pharmacology</jtitle><addtitle>Fundam Clin Pharmacol</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>13</volume><issue>2</issue><spage>226</spage><epage>231</epage><pages>226-231</pages><issn>0767-3981</issn><eissn>1472-8206</eissn><coden>FCPHEZ</coden><abstract>— This study is aimed at evaluating the influence of the cytochrome P450 arachidonate metabolites on the renal alterations exhibited by the Lyon hypertensive (LH) rat. To that purpose, kidneys were isolated from LH rats and their normotensive (LN) controls and single‐pass perfused at different pressure levels before (control conditions) and after cytochrome P450 inhibition by 7‐ethoxyresorufin (7‐ER, 1 μM). In control conditions, LH kidneys differed from LN ones by an increased preglomerular resistance and a blunted pressure natriuresis. 7‐ER, which did not affect the function of LN kidneys, decreased the vascular resistance of LH kidneys, increased their glomerular filtration rate but had no effect on their pressure natriuresis. These results indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional alterations exhibited by LH kidneys.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10226768</pmid><doi>10.1111/j.1472-8206.1999.tb00343.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0767-3981 |
| ispartof | Fundamental & clinical pharmacology, 1999-01, Vol.13 (2), p.226-231 |
| issn | 0767-3981 1472-8206 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69726550 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Arachidonic Acid - metabolism Biological and medical sciences Cyclic GMP - metabolism Cytochrome P-450 Enzyme System - metabolism cytochrome P450 Dose-Response Relationship, Drug Glomerular Filtration Rate Hypertension - enzymology Hypertension - genetics hypertensive rat In Vitro Techniques kidney Kidney - drug effects Kidney - enzymology Kidney - metabolism Kidney Function Tests Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Prostaglandins F - metabolism Rats Renal Circulation - physiology Renovascular diseases Sodium - metabolism Thromboxane B2 - metabolism |
| title | Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T18%3A47%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20effects%20of%20cP450%20arachidonate%20metabolites%20in%20the%20Lyon%20hypertensive%20rat&rft.jtitle=Fundamental%20&%20clinical%20pharmacology&rft.au=Monneret,%20Guillaume&rft.date=1999-01-01&rft.volume=13&rft.issue=2&rft.spage=226&rft.epage=231&rft.pages=226-231&rft.issn=0767-3981&rft.eissn=1472-8206&rft.coden=FCPHEZ&rft_id=info:doi/10.1111/j.1472-8206.1999.tb00343.x&rft_dat=%3Cproquest_cross%3E69726550%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4373-8b2e99552669923d3a2b28783763057f5c408353a4b2b64d4ba5bac3d8afcf033%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69726550&rft_id=info:pmid/10226768&rfr_iscdi=true |