Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov

Information from a scrapie epidemic in a closed INRA Romanov flock is presented. Performances, pedigree, histopathological diagnoses and PrP genotypes were recorded from the beginning of the outbreak (in 1993). Between 1st of April, 1993 and 1st of May, 1997, 1015 animals were exposed to scrapie, an...

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Bibliographic Details
Published in:Archives of virology 1999-01, Vol.144 (3), p.431-445
Main Authors: Elsen, J.M, Amigues, Y, Schelcher, F, Ducrocq, V, Andreoletti, O, Eychenne, F, Tien Khang, J.V, Poivey, J.P, Lantier, F, Laplanche, J.L
Format: Article
Language:English
Subjects:
Animal productions
Animal viral diseases
Animals
artificial rearing
Biological and medical sciences
Disease Outbreaks
France - epidemiology
Fundamental and applied biological sciences. Psychology
gender differences
Genetic Predisposition to Disease - genetics
genetic resistance
genotype
Infectious diseases
maternal transmission
Medical sciences
mortality
outbreaks
Prions - genetics
Romanov
scrapie
Scrapie - epidemiology
Scrapie - genetics
Scrapie - pathology
Scrapie - transmission
Sheep
Teladorsagia circumcincta
Terrestrial animal productions
Vertebrates
Viral diseases
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Summary:Information from a scrapie epidemic in a closed INRA Romanov flock is presented. Performances, pedigree, histopathological diagnoses and PrP genotypes were recorded from the beginning of the outbreak (in 1993). Between 1st of April, 1993 and 1st of May, 1997, 1015 animals were exposed to scrapie, and 304 died from this disease. A major influence of the polymorphisms at codons 136, 154 and 171 is shown, A136H154Q171 allele carriers proving to be nearly as resistant as A136R154R171 carriers. A possible relationship between gastrointestinal parasitism and scrapie is discussed. There is evidence of maternal transmission, with a risk ratio for artificially fed lambs of 67 percent of the risk of lambs fed by their mother. Our results strongly suggest that resistant animals were not healthy carriers or at least were less infectious when comparing risk for lambs born to healthy dams either of resistant (risk = 0.431) or of susceptible (risk = 1.000) genotype.
ISSN:0304-8608
1432-8798
DOI:10.1007/s007050050516