MicroRNAs - micro in size but macro in function

MicroRNAs (miRNAs) are endogenous small RNAs that can regulate target mRNAs by binding to their 3'-UTRs. A single miRNA can regulate many mRNA targets, and several miRNAs can regulate a single mRNA. These have been reported to be involved in a variety of functions, including developmental trans...

Full description

Saved in:
Bibliographic Details
Published in:The FEBS journal 2008-10, Vol.275 (20), p.4929-4944
Main Authors: Singh, Sunit K, Pal Bhadra, Manika, Girschick, Hermann J, Bhadra, Utpal
Format: Article
Language:English
Subjects:
Animals
Binding sites
Biochemistry
Biomedical research
Dicer
Disease - genetics
Gene Expression Regulation
Genetics
Growth and Development - genetics
Humans
microRNA
MicroRNAs - biosynthesis
MicroRNAs - genetics
MicroRNAs - physiology
miRNA and cancer
miRNA and disease
miRNA and therapeutics
miRNA biogenesis
miRNA function
miRNA inhibitors
Ribonucleic acid
RNA
small RNA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MicroRNAs (miRNAs) are endogenous small RNAs that can regulate target mRNAs by binding to their 3'-UTRs. A single miRNA can regulate many mRNA targets, and several miRNAs can regulate a single mRNA. These have been reported to be involved in a variety of functions, including developmental transitions, neuronal patterning, apoptosis, adipogenesis metabolism and hematopoiesis in different organisms. Many oncogenes and tumor suppressor genes are regulated by miRNAs. Studies conducted in the past few years have demonstrated the possible association between miRNAs and several human malignancies and infectious diseases. In this article, we have focused on the mechanism of miRNA biogenesis and the role of miRNAs in human health and disease.
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2008.06624.x