Bacterial invasion: Force feeding by Salmonella

Recent findings have shed new light on mammalian-cell invasion by Salmonella. Using a type III secretion system, Salmonella deliver virulence factors into the host cell that directly activate signal transduction pathways, initiating cytoskeletal rearrangements and bacterial uptake by a ruffling mech...

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Bibliographic Details
Published in:Current biology 1999-04, Vol.9 (8), p.R277-R280
Main Authors: Brumell, John H., Steele-Mortimer, Olivia, Finlay, B.Brett
Format: Article
Language:English
Subjects:
Animals
Bacterial Infections - metabolism
Bacterial Infections - physiopathology
Bacterial Proteins - metabolism
Salmonella
Salmonella Infections, Animal - metabolism
Salmonella Infections, Animal - physiopathology
Salmonella typhimurium - growth & development
Salmonella typhimurium - pathogenicity
Signal Transduction
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Summary:Recent findings have shed new light on mammalian-cell invasion by Salmonella. Using a type III secretion system, Salmonella deliver virulence factors into the host cell that directly activate signal transduction pathways, initiating cytoskeletal rearrangements and bacterial uptake by a ruffling mechanism.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(99)80178-X