Renal epithelial polarity in health and disease

Epithelial cells mediate the unidirectional movement of selective compounds from one biological compartment to another. This is accomplished by having biochemically, structurally, and functionally distinctive apical and basolateral surface membrane domains separated by the cells' junctional com...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1999-02, Vol.13 (2), p.163-170
Main Authors: WAGNER, M. C, MOLITORIS, B. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells
Cytoskeleton
Epithelial Cells - physiology
Extracellular matrix
Fundamental and applied biological sciences. Psychology
Health
Humans
Ischemia
Kidney - cytology
Kidney - pathology
Kidney - physiology
Kidney - ultrastructure
Kidney diseases
Kidney Diseases - pathology
Kidney Diseases - physiopathology
Kidneys
Medical sciences
Nephrology. Urinary tract diseases
Physiology
Proteins
Urinary system involvement in other diseases. Miscellaneous
Urothelium - pathology
Vertebrates: urinary system
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Description
Summary:Epithelial cells mediate the unidirectional movement of selective compounds from one biological compartment to another. This is accomplished by having biochemically, structurally, and functionally distinctive apical and basolateral surface membrane domains separated by the cells' junctional complex. Derangement of this highly ordered situation can result in cell injury, dysfunction, and even death. For renal epithelial cells, both ischemia and polycystic kidney disease are known to result in a loss of surface membrane polarity. In both disease processes, this in turn plays an important role in cell and organ dysfunction.
ISSN:0931-041X
1432-198X
DOI:10.1007/s004670050586