Investigation of new potent KDO-8-phosphate synthetase inhibitors

A total synthesis of ( Z, E)-D-Glucophosphoenolpyruvate and its carboxylic ester derivatives is described in four or five steps from 2,3:5,6-Di- O-isopropylidene-4- O- t-butyldimethylsilyl-D-glucose A total synthesis of ( Z, E)-D-Glucophosphoenolpyru vate 5 (R=H, Me, i-Pr) is described in four or fi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-04, Vol.9 (7), p.949-952
Main Authors: Coutrot, Ph, Dumarçay, S., Finance, Ch, Tabyaoui, M., Tabyaoui, B., Grison, C.
Format: Article
Language:English
Subjects:
Aldehyde-Lyases - antagonists & inhibitors
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - enzymology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
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Summary:A total synthesis of ( Z, E)-D-Glucophosphoenolpyruvate and its carboxylic ester derivatives is described in four or five steps from 2,3:5,6-Di- O-isopropylidene-4- O- t-butyldimethylsilyl-D-glucose A total synthesis of ( Z, E)-D-Glucophosphoenolpyru vate 5 (R=H, Me, i-Pr) is described in four or five steps from 2,3;5,6-Di- O-isopropylidene-4- O-t-butyldimethylsilyl-D-glucose 1
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00111-0