Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast

A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the b...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1999-05, Vol.59 (9), p.2041-2044
Main Authors: TANAKA, T, KIMURA, M, MATSUNAGA, K, FUKADA, D, MORI, H, OKANO, Y
Format: Article
Language:English
Subjects:
Anaphase
Aneuploidy
Aurora Kinases
Biological and medical sciences
Breast - enzymology
Breast Diseases - enzymology
Breast Neoplasms - enzymology
Breast Neoplasms - genetics
Carcinoma, Ductal, Breast - enzymology
Carcinoma, Ductal, Breast - genetics
Cell Division
Centrosome - enzymology
Chromosomes, Human, Pair 20 - genetics
Female
Gene Expression Regulation, Neoplastic
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Oncogenes
Proliferating Cell Nuclear Antigen - analysis
Protein Kinases - biosynthesis
Protein Kinases - genetics
Protein-Serine-Threonine Kinases
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells. Benign breast lesions including fibrocystic disease and fibroadenoma (epithelial components) displayed weakly detectable AIK1 expression in part of the lesions. This is the first immunohistochemical report of AIK1 expression in primary human breast carcinomas. Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells.
ISSN:0008-5472
1538-7445