Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast

• Published in: Cancer research (Chicago, Ill.) Ill.), 1999-05, Vol.59 (9), p.2041-2044
• Main Authors: TANAKA, T, KIMURA, M, MATSUNAGA, K, FUKADA, D, MORI, H, OKANO, Y
• Format: Article
• Language: English
• Subjects: Anaphase; Aneuploidy; Aurora Kinases; Biological and medical sciences; Breast - enzymology; Breast Diseases - enzymology; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Carcinoma, Ductal, Breast - enzymology; Carcinoma, Ductal, Breast - genetics; Cell Division; Centrosome - enzymology; Chromosomes, Human, Pair 20 - genetics; Female; Gene Expression Regulation, Neoplastic; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; Oncogenes; Proliferating Cell Nuclear Antigen - analysis; Protein Kinases - biosynthesis; Protein Kinases - genetics; Protein-Serine-Threonine Kinases; Tumors
• ISSN: 0008-5472; 1538-7445

A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells. Benign breast lesions including fibrocystic disease and fibroadenoma (epithelial components) displayed weakly detectable AIK1 expression in part of the lesions. This is the first immunohistochemical report of AIK1 expression in primary human breast carcinomas. Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells.