Mannose-binding lectin gene polymorphisms in relation to periodontitis

Aim: To investigate the correlation of six functional polymorphisms in the MBL gene with MBL plasma levels in relation to periodontitis. Material and Methods: A total of 92 periodontitis patients and 70 controls, all of Caucasian origin, were included. Patients and controls were genotyped for the L/...

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Published in:Journal of clinical periodontology 2008-11, Vol.35 (11), p.923-930
Main Authors: Louropoulou, Anna, Van Der Velden, Ubele, Schoenmaker, Ton, Catsburg, Arnold, Savelkoul, Paul H. M., Loos, Bruno G.
Format: Article
Language:English
Subjects:
acute phase reactant
Acute-Phase Proteins - genetics
Adult
Aged
Biological and medical sciences
Case-Control Studies
Dentistry
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
genotyping
Humans
Male
Mannose-Binding Lectin - blood
Mannose-Binding Lectin - deficiency
Mannose-Binding Lectin - genetics
MBL
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
periodontitis
Periodontitis - blood
Periodontitis - genetics
Polymorphism, Single Nucleotide
Regression Analysis
Statistics, Nonparametric
Young Adult
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Summary:Aim: To investigate the correlation of six functional polymorphisms in the MBL gene with MBL plasma levels in relation to periodontitis. Material and Methods: A total of 92 periodontitis patients and 70 controls, all of Caucasian origin, were included. Patients and controls were genotyped for the L/H, X/Y, P/Q, A/D, A/B and A/C polymorphisms. Distributions of genotypes, rate of allele carriage and allele frequencies were compared between patients and controls. Patients and controls were subdivided in groups of genotypes. Plasma MBL levels were compared between different genotype groups. Results: On the basis of genotyping, three phenotypes with regard to mannose‐binding lectin (MBL) production were distinguished: high‐producers, low‐producers and deficient subjects. No differences in the genotype frequencies were observed between patients and controls. Within patients and controls, subjects with the high‐producing genotypes had significantly higher MBL plasma levels than low‐producers and deficient subjects (p
ISSN:0303-6979
1600-051X
DOI:10.1111/j.1600-051X.2008.01311.x