Porous red cell ultrastructure and loss of membrane asymmetry in a novel case of hemolytic anemia

Transmission electron microscopic study revealed large pores on the erythrocyte ghost membranes, disrupted cytoskeleton and microcytosis of circulating erythrocytes in a novel case of hemolytic anemia. Greater loss of phosphatidylserine (PS) asymmetry was observed in younger erythrocytes compared wi...

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Bibliographic Details
Published in:European journal of haematology 2008-11, Vol.81 (5), p.399-402
Main Authors: Banerjee, Debasis, Saha, Sutapa, Basu, Sumanta, Chakrabarti, Abhijit
Format: Article
Language:English
Subjects:
Anemia, Hemolytic - metabolism
Anemia, Hemolytic - pathology
Child, Preschool
Cytoskeleton - metabolism
Cytoskeleton - ultrastructure
Erythrocyte Membrane - metabolism
Erythrocyte Membrane - ultrastructure
Glycophorin - metabolism
Humans
Male
membrane asymmetry
microcytosis
Microscopy, Electron, Transmission - methods
Phagocytes - metabolism
Phagocytes - ultrastructure
Phosphatidylserines - metabolism
porous ultrastructure
red cell
Wheat Germ Agglutinins - chemistry
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Summary:Transmission electron microscopic study revealed large pores on the erythrocyte ghost membranes, disrupted cytoskeleton and microcytosis of circulating erythrocytes in a novel case of hemolytic anemia. Greater loss of phosphatidylserine (PS) asymmetry was observed in younger erythrocytes compared with the aged ones in contrast to the normal red cells. Levels of sialylated glycoconjugates, such as glycophorin, measured by the binding of wheat germ agglutinin, showed greater loss upon aging. Such drastic loss of PS asymmetry leads to faster eryptosis, mediated by shedding of glycophorin‐containing microvesicles leaving highly PS‐exposed erythrocytes accessible to the phagocytes.
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2008.01153.x