Urinary nuclear matrix protein 22 (NMP22): A diagnostic adjunct to urine cytologic examination for the detection of recurrent transitional-cell carcinoma of the bladder

• Published in: Diagnostic cytopathology 1999-05, Vol.20 (5), p.285-290
• Main Authors: Hughes, Jonathan H., Katz, Ruth L., Rodriguez-Villanueva, Julio, Kidd, Larry, Dinney, Colin, Grossman, H. Barton, Fritsche Jr, Herbert A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Transitional Cell - pathology; Carcinoma, Transitional Cell - urine; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Neoplasm Staging; nuclear matrix proteins; Nuclear Proteins - urine; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; transitional-cell carcinoma; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - urine; Urinary system; urinary tract cytology
• ISSN: 8755-1039; 1097-0339
• DOI: 10.1002/(SICI)1097-0339(199905)20:5<285::AID-DC7>3.0.CO;2-T

This study compares urine nuclear matrix protein 22 (NMP22) immunoassay and conventional urine cytologic examination for detecting recurrent transitional‐cell carcinoma (TCC) of the urinary bladder. One hundred twenty‐eight urine specimens from 107 patients with a history of TCC of the urinary bladder were studied. NMP22 immunoassay and conventional cytologic examination were performed on each specimen. The NMP22 and cytology results were then compared with the results of subsequent cystoscopies/surgical biopsies performed over a 6‐mo follow‐up period. The sensitivity of urine cytologic study for predicting recurrent TCC was 60%, while the sensitivity of NMP22 assay was 47%. When both NMP22 assay results and the cytologic interpretation were positive for TCC, the positive predictive value of the combined tests was 74%. When both tests showed negative results, the negative predictive power was 81%. Our findings suggest that urine NMP22 assay may represent a useful diagnostic adjunct to conventional urine cytologic examination for the detection of recurrent TCC of the urinary bladder. Diagn. Cytopathol. 1999;20:285–290. © 1999 Wiley‐Liss, Inc.