Cryo Electron Tomography Reveals Confined Complex Morphologies of Tripeptide-Containing Amphiphilic Double-Comb Diblock Copolymers

Sequence sets structure: Amphiphilic norbornene‐based double‐comb diblock polymers with peptide and oligo(ethylene oxide) side chains aggregate in water to form unprecedented complex morphologies depending on the amino acid sequence of the peptide. The internal structures of the aggregates observed...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (46), p.8859-8862
Main Authors: Parry, Alison L, Bomans, Paul H.H, Holder, Simon J, Sommerdijk, Nico A.J.M, Biagini, Stefano C.G
Format: Article
Language:English
Subjects:
aggregation
branching
Cryoelectron Microscopy
electron microscopy
Hydrophobic and Hydrophilic Interactions
Microscopy, Electron, Transmission
Molecular Structure
Peptides - chemistry
Polymers - chemistry
polynorbornene
self‐assembly
Water - chemistry
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Summary:Sequence sets structure: Amphiphilic norbornene‐based double‐comb diblock polymers with peptide and oligo(ethylene oxide) side chains aggregate in water to form unprecedented complex morphologies depending on the amino acid sequence of the peptide. The internal structures of the aggregates observed by cryo electron tomography show densely folded and highly branched wormlike micelles (left) and spherical aggregates with a bicontinuous architecture (right).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200802834