Polyketides from a marine sponge-derived fungus Mycelia sterilia and proton-proton long-range coupling

A series of polyketide‐originated metabolites (1–5) were isolated from a marine sponge‐derived fungus Mycelia sterilia. Of these, 1–3 were new compounds. Their structures were elucidated by spectroscopic methods as (4R*, 5S*, 6S*, 8S*, 13R*)‐1‐(2,8‐dihydroxy‐1,2,6‐trimethyl‐1,2,6,7,8,8a‐hexahydro‐na...

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Published in:Magnetic resonance in chemistry 2008-12, Vol.46 (12), p.1148-1152
Main Authors: Hao, Gao, Qing-Hua, Zhang, Miao-Miao, Jiang, Jin-Shan, Tang, Cheng-Du, Miao, Kui, Hong, Michio, Namikoshi, Nai-Li, Wang, Xin-Sheng, Yao
Format: Article
Language:English
Subjects:
13C NMR
1D selective NOESY
1H NMR
2D NMR
allylic coupling
Animals
Fungi - chemistry
homoallylic coupling
Macrolides - chemistry
Magnetic Resonance Spectroscopy - methods
Mycelia sterilia
Naphthalenes - chemistry
polyketides
Porifera - microbiology
proton-proton long-range coupling
sponge-derived fungus
Stereoisomerism
W-relationship coupling
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Summary:A series of polyketide‐originated metabolites (1–5) were isolated from a marine sponge‐derived fungus Mycelia sterilia. Of these, 1–3 were new compounds. Their structures were elucidated by spectroscopic methods as (4R*, 5S*, 6S*, 8S*, 13R*)‐1‐(2,8‐dihydroxy‐1,2,6‐trimethyl‐1,2,6,7,8,8a‐hexahydro‐naphthalen‐1‐yl)‐3‐methoxy‐propan‐1‐one (1), 4,8‐dihydroxy‐7‐(2‐hydroxy‐ethyl)‐6‐methoxy‐3,4‐dihydro‐2H‐naphthalen‐1‐one (2) and 1‐methyl‐naphthalene‐2,6‐dicarboxylic acid (3). In 1, the proton–proton long‐range coupling phenomenon claimed attention and was discussed. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.2338