Cell-cycle inhibitor p27/Kip-1 expression in non-astrocytic and non-oligodendrocytic human nervous system tumors

p27/kip-1 is a `universal inhibitor' which inhibits cyclin complexes with cyclin-dependent kinases (CDKs), preventing cell cycle from the G1-S progression. It is expressed in normal oligodendrocytes and in differentiated glial tumors, decreasing with anaplasia and malignancy. In non-astrocytic...

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Bibliographic Details
Published in:Neuroscience letters 1999-04, Vol.264 (1), p.29-32
Main Authors: Schiffer, D, Bortolotto, S, Bosone, I, Cancelli, I, Cavalla, P, Schiffer, P, Piva, R
Format: Article
Language:English
Subjects:
Apoptosis - physiology
Biological and medical sciences
Cell Cycle - physiology
Cell Cycle Proteins
Cell Differentiation - physiology
Cyclin-Dependent Kinase Inhibitor p27
Ependymoma - metabolism
Ependymoma - pathology
Humans
Immunohistochemistry
Medical sciences
Medulloblastoma - metabolism
Medulloblastoma - pathology
Meningioma - metabolism
Meningioma - pathology
Microtubule-Associated Proteins - metabolism
Nervous System Neoplasms - metabolism
Nervous System Neoplasms - pathology
Nervous system tumors
Neuroblastoma - metabolism
Neuroblastoma - pathology
Neurology
p27/kip-1
Tumor Suppressor Proteins
Tumors of the nervous system. Phacomatoses
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Summary:p27/kip-1 is a `universal inhibitor' which inhibits cyclin complexes with cyclin-dependent kinases (CDKs), preventing cell cycle from the G1-S progression. It is expressed in normal oligodendrocytes and in differentiated glial tumors, decreasing with anaplasia and malignancy. In non-astrocytic and non-oligodendrocytic tumors of the nervous system, such as meningiomas, schwannomas, medulloblastomas, neuroblastomas and malignant lymphomas, p27/kip-1 is inconstantly and sometimes poorly expressed. This can be due to the lacking of p27 expression in the normal counterpart of tumor cells. In some tumors, p27/kip-1 expression can be attributed to a differentiation process, as in the pale islands of desmoplastic medulloblastoma and in neuroblastomas. A correlation of p27/kip-1 expression with histology was not found, with the exception of apoptosis in medulloblastomas. p27/kip-1 is in feed-back with cyclins and CDKs for the control of cell proliferation and its expression may occur where requested by the interplay with cyclins and other inhibitors.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00171-8