Preliminary results of intraoperative photodynamic therapy with 5-aminolevulinic acid in dogs with prostate carcinoma

Six client-owned dogs with prostate carcinoma were treated with a combination of (1) partial subcapsular prostatectomy using an Nd:YAG laser, (2) intraoperative photodynamic therapy using a halogen broad band lamp after local administration of a photosensitiser, and (3) systemic treatment with melox...

Full description

Saved in:
Bibliographic Details
Published in:The veterinary journal (1997) 2008-11, Vol.178 (2), p.202-207
Main Authors: L’Eplattenier, H.F., Klem, B., Teske, E., van Sluijs, F.J., van Nimwegen, S.A., Kirpensteijn, J.
Format: Article
Language:English
Subjects:
5-aminolevulinic acid
ALA
aminolevulinic acid
Aminolevulinic Acid - analogs & derivatives
Aminolevulinic Acid - therapeutic use
Animals
Combined Modality Therapy
disease course
Dog
dog diseases
Dog Diseases - drug therapy
Dog Diseases - surgery
Dogs
interleukin-2
Intraoperative
Intraoperative Care
lasers
light
Male
metastasis
mortality
Neoplasm Recurrence, Local - veterinary
new methods
new technology
photochemistry
Photochemotherapy - methods
Photochemotherapy - veterinary
Photodynamic therapy
photosensitisers
Photosensitizing Agents - therapeutic use
Prostate carcinoma
Prostatectomy - veterinary
prostatic neoplasms
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - surgery
Prostatic Neoplasms - veterinary
protective effect
surgery
therapeutics
tissue degeneration
topical application
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Six client-owned dogs with prostate carcinoma were treated with a combination of (1) partial subcapsular prostatectomy using an Nd:YAG laser, (2) intraoperative photodynamic therapy using a halogen broad band lamp after local administration of a photosensitiser, and (3) systemic treatment with meloxicam. Median survival time was 41 days (range 10–68 days), which compared negatively with previous reports of subtotal laser prostatectomy combined with topical interleukin-2 administration, and photodynamic therapy alone. Despite treatment, the disease progressed locally, causing signs of stranguria to recur, and in the form of distant metastases. The recurrence of clinical signs due to the primary tumour despite photodynamic therapy is probably largely explained by insufficient penetration of light into the tissue. Better results may be obtained using other light sources (e.g. laser) and alternative techniques of light delivery, such as fibres or catheters allowing interstitial diffusion of light.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2007.08.001