Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling

Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and poo...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1999-02, Vol.192 (1-2), p.95-103
Main Authors: Knudsen, J, Jensen, M V, Hansen, J K, Faergeman, N J, Neergaard, T B, Gaigg, B
Format: Article
Language:English
Subjects:
Acyl Coenzyme A - analysis
Acyl Coenzyme A - metabolism
Animals
Carrier Proteins - physiology
Cytosol - metabolism
Diazepam Binding Inhibitor
Escherichia coli - enzymology
Esters
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Fungal
Metabolites
Models, Biological
Proteins
Rats
Saccharomyces cerevisiae - enzymology
Sequence Homology, Amino Acid
Signal Transduction
Tissue Distribution
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Summary:Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].
ISSN:0300-8177
1573-4919
DOI:10.1023/a:1006830606060