Centromere proteins and chromosome inheritance: a complex affair

Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inherit...

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Bibliographic Details
Published in:Current opinion in genetics & development 1999-04, Vol.9 (2), p.206-217
Main Authors: Dobie, Kenneth W, Hari, Kumar L, Maggert, Keith A, Karpen, Gary H
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - genetics
Centromere - metabolism
Chromosomal Proteins, Non-Histone - metabolism
Microtubules - metabolism
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Summary:Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inheritance with the cell cycle in several organisms. A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(99)80031-8