Mechanisms of cellular uptake of long chain free fatty acids

Cells take up long chain free fatty acids (FFA) in vivo from the non-protein bound ligand pools in extracellular fluid and plasma, which contain approximately 100 and 600 microM albumin, respectively. The physiologic range of unbound FFA concentrations in such fluids has traditionally been calculate...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1999-02, Vol.192 (1-2), p.17-31
Main Authors: Berk, P D, Stump, D D
Format: Article
Language:English
Subjects:
Animal models
Animals
Carrier Proteins - physiology
Disease Models, Animal
Dose-Response Relationship, Drug
Fatty acids
Fatty Acids, Nonesterified - metabolism
Kinetics
Membranes
Models, Biological
Oleic Acid - pharmacology
Plasma
Rats
Rats, Wistar
Rats, Zucker
Serum Albumin, Bovine - pharmacology
Temperature
Time Factors
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Summary:Cells take up long chain free fatty acids (FFA) in vivo from the non-protein bound ligand pools in extracellular fluid and plasma, which contain approximately 100 and 600 microM albumin, respectively. The physiologic range of unbound FFA concentrations in such fluids has traditionally been calculated at
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1006832001033