Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients

Abstract This study was conducted to assess the relationship among circulating markers of inflammation, endothelial dysfunction and angiogenesis in 59 chronic heart failure (CHF) patients. Increased concentrations of C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), von Willebrand factor (...

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Bibliographic Details
Published in:International journal of cardiology 2008-11, Vol.130 (2), p.276-277
Main Authors: Vila, Virtudes, Martínez-Sales, Vicenta, Almenar, Luis, Lázaro, Ignacio Sánchez, Villa, Piedad, Reganon, Edelmiro
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Cardiovascular
Chronic Disease
Chronic heart failure
Endothelial dysfunction angiogenesis
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Heart
Heart Failure - blood
Heart Failure - diagnosis
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Inflammation
Inflammation Mediators - blood
Medical sciences
Middle Aged
Neovascularization, Pathologic - blood
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Summary:Abstract This study was conducted to assess the relationship among circulating markers of inflammation, endothelial dysfunction and angiogenesis in 59 chronic heart failure (CHF) patients. Increased concentrations of C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), von Willebrand factor (VWF) and fibrinogen are strongly implicated in the development of CHF. Increased vascular endothelium grow factor (VEGF) and decreased thrombospondin-1 (TSP-1) concentrations suggest a role of angiogenesis in the maintenance and repair of luminal endothelium in CHF. A relationship among markers of endothelial dysfunction (VWF) and inflammation (fibrinogen, CRP) and angiogenesis (VEGF, TSP-1) was found in CHF patients.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2007.07.010