Pemphigoid vegetans: a case report and review of the literature

Pemphigoid vegetans is an exceptionally rare intertriginous variant of bullous pemphigoid characterized by vegetative and purulent lesions present in the groin, axillae, thighs, hands, eyelids and perioral regions. The clinical, histopathological and immunofluorescent profile of a new case of pemphi...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2008-12, Vol.35 (12), p.1144-1147
Main Authors: Kim, Jinah, Chavel, Severine, Girardi, Michael, McNiff, Jennifer M.
Format: Article
Language:English
Subjects:
Aged
Anti-Infective Agents - therapeutic use
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Bullous diseases of the skin
Chlorhexidine - analogs & derivatives
Chlorhexidine - therapeutic use
Clobetasol - therapeutic use
Dermatology
Fluorescent Antibody Technique
Humans
Immunosuppressive Agents - therapeutic use
Male
Medical sciences
Pemphigoid, Bullous - drug therapy
Pemphigoid, Bullous - metabolism
Pemphigoid, Bullous - pathology
Tacrolimus - therapeutic use
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
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Summary:Pemphigoid vegetans is an exceptionally rare intertriginous variant of bullous pemphigoid characterized by vegetative and purulent lesions present in the groin, axillae, thighs, hands, eyelids and perioral regions. The clinical, histopathological and immunofluorescent profile of a new case of pemphigoid vegetans in a 79‐year‐old man is reported. Our patient had papillomatous plaques with pustules in the bilateral inguinal folds, which clinically resembled pemphigus vegetans. Also suggesting pemphigus vegetans, an initial skin biopsy showed eosinophilic spongiosis, while a second biopsy showed histological and immunological features diagnostic of pemphigoid. Because only a few cases of pemphigoid vegetans have been reported in the literature, clinical and morphological data are scant. Most reported cases were successfully treated with topical antibiotics or steroids; therefore, appropriate diagnosis of this rare lesion will assist management.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.1600-0560.2008.01016.x