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Salivary duct carcinoma in situ of the parotid gland
Aims: To describe three cases of purely in situ salivary duct carcinoma, so as better to define the entity. Methods and results: Three primary tumours of the parotid gland are presented, in each case composed of cysts and ducts and lined by high nuclear grade epithelial cells. All parts of each tu...
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Published in: | Histopathology 2008-10, Vol.53 (4), p.416-425 |
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creator | Simpson, R H W Desai, S Di Palma, S |
description | Aims: To describe three cases of purely in situ salivary duct carcinoma, so as better to define the entity.
Methods and results: Three primary tumours of the parotid gland are presented, in each case composed of cysts and ducts and lined by high nuclear grade epithelial cells. All parts of each tumour were surrounded by a myoepithelial cell rim and there was no evidence of invasion. The tumour cells expressed immunohistochemical markers seen in invasive salivary duct carcinoma of usual (high‐grade) type. In two cases the androgen receptor (AR) reaction was strong, but there was no immunohistochemical expression of HER2 protein or gene amplification by in situ hybridization. In the remaining case, fewer nuclei stained for AR, but both HER2 protein and gene amplification were demonstrated.
Conclusions: Salivary duct carcinoma in situ is morphologically similar to breast ductal carcinoma in situ and, although our cases are few, salivary duct carcinoma in situ can possibly be subdivided into luminal and non‐luminal cell types, as can analogous mammary neoplasms. The present study cannot determine whether low‐grade cribriform cystadenocarcinoma, architecturally similar but immunohistochemically different, is part of the spectrum of salivary duct carcinoma in situ, or whether it represents a separate entity. |
doi_str_mv | 10.1111/j.1365-2559.2008.03135.x |
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Methods and results: Three primary tumours of the parotid gland are presented, in each case composed of cysts and ducts and lined by high nuclear grade epithelial cells. All parts of each tumour were surrounded by a myoepithelial cell rim and there was no evidence of invasion. The tumour cells expressed immunohistochemical markers seen in invasive salivary duct carcinoma of usual (high‐grade) type. In two cases the androgen receptor (AR) reaction was strong, but there was no immunohistochemical expression of HER2 protein or gene amplification by in situ hybridization. In the remaining case, fewer nuclei stained for AR, but both HER2 protein and gene amplification were demonstrated.
Conclusions: Salivary duct carcinoma in situ is morphologically similar to breast ductal carcinoma in situ and, although our cases are few, salivary duct carcinoma in situ can possibly be subdivided into luminal and non‐luminal cell types, as can analogous mammary neoplasms. The present study cannot determine whether low‐grade cribriform cystadenocarcinoma, architecturally similar but immunohistochemically different, is part of the spectrum of salivary duct carcinoma in situ, or whether it represents a separate entity.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2008.03135.x</identifier><identifier>PMID: 18983607</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma in Situ - metabolism ; Carcinoma in Situ - pathology ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; parotid gland ; Parotid Gland - pathology ; Parotid Neoplasms - metabolism ; Parotid Neoplasms - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Receptor, ErbB-2 - metabolism ; Receptors, Androgen - metabolism ; Salivary Ducts - pathology ; salivary gland neoplasms ; silver in situ hybridization</subject><ispartof>Histopathology, 2008-10, Vol.53 (4), p.416-425</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Publishing Limited</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5515-59f28700820784997f4a7b2b4baed1191aaeb2ec670ec9e27fe033a6a7df4b0d3</citedby><cites>FETCH-LOGICAL-c5515-59f28700820784997f4a7b2b4baed1191aaeb2ec670ec9e27fe033a6a7df4b0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20697101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18983607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simpson, R H W</creatorcontrib><creatorcontrib>Desai, S</creatorcontrib><creatorcontrib>Di Palma, S</creatorcontrib><title>Salivary duct carcinoma in situ of the parotid gland</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims: To describe three cases of purely in situ salivary duct carcinoma, so as better to define the entity.
Methods and results: Three primary tumours of the parotid gland are presented, in each case composed of cysts and ducts and lined by high nuclear grade epithelial cells. All parts of each tumour were surrounded by a myoepithelial cell rim and there was no evidence of invasion. The tumour cells expressed immunohistochemical markers seen in invasive salivary duct carcinoma of usual (high‐grade) type. In two cases the androgen receptor (AR) reaction was strong, but there was no immunohistochemical expression of HER2 protein or gene amplification by in situ hybridization. In the remaining case, fewer nuclei stained for AR, but both HER2 protein and gene amplification were demonstrated.
Conclusions: Salivary duct carcinoma in situ is morphologically similar to breast ductal carcinoma in situ and, although our cases are few, salivary duct carcinoma in situ can possibly be subdivided into luminal and non‐luminal cell types, as can analogous mammary neoplasms. The present study cannot determine whether low‐grade cribriform cystadenocarcinoma, architecturally similar but immunohistochemically different, is part of the spectrum of salivary duct carcinoma in situ, or whether it represents a separate entity.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma in Situ - metabolism</subject><subject>Carcinoma in Situ - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>parotid gland</subject><subject>Parotid Gland - pathology</subject><subject>Parotid Neoplasms - metabolism</subject><subject>Parotid Neoplasms - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Receptors, Androgen - metabolism</subject><subject>Salivary Ducts - pathology</subject><subject>salivary gland neoplasms</subject><subject>silver in situ hybridization</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u1DAURq2Kig6FV6i8gV3CtR3H9qILGNEfqWoXBbG0bhwHPM1MBjuB6dvjMKNhW29syefz_XwIoQxKltfHVclELQsupSk5gC5BMCHL3QlZHC9ekQUIMAWwWp2RNymtAJgSnL8mZ0wbLWpQC1I9Yh9-Y3ym7eRG6jC6sBnWSMOGpjBOdOjo-NPTLcZhDC390eOmfUtOO-yTf3fYz8m3qy9flzfF3cP17fLTXeGkZLKQpuNa5XoclK6MUV2FquFN1aBvGTMM0Tfcu1qBd8Zz1XkQAmtUbVc10Ipz8mH_7jYOvyafRrsOyfk-d_DDlGxtlBQMZAb1HnRxSCn6zm5jWOdfWQZ2NmZXdhZjZzF2Nmb_GbO7HL04zJiatW__Bw-KMvD-AGBy2HcRNy6kI8cht2DAMne55_6E3j-_uIC9uX2cTzlf7PMhjX53zGN8srUSStrv99d2efVZL02lrRZ_AU6ZlFg</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Simpson, R H W</creator><creator>Desai, S</creator><creator>Di Palma, S</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>Salivary duct carcinoma in situ of the parotid gland</title><author>Simpson, R H W ; Desai, S ; Di Palma, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5515-59f28700820784997f4a7b2b4baed1191aaeb2ec670ec9e27fe033a6a7df4b0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma in Situ - metabolism</topic><topic>Carcinoma in Situ - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>parotid gland</topic><topic>Parotid Gland - pathology</topic><topic>Parotid Neoplasms - metabolism</topic><topic>Parotid Neoplasms - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Receptor, ErbB-2 - metabolism</topic><topic>Receptors, Androgen - metabolism</topic><topic>Salivary Ducts - pathology</topic><topic>salivary gland neoplasms</topic><topic>silver in situ hybridization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simpson, R H W</creatorcontrib><creatorcontrib>Desai, S</creatorcontrib><creatorcontrib>Di Palma, S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simpson, R H W</au><au>Desai, S</au><au>Di Palma, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary duct carcinoma in situ of the parotid gland</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2008-10</date><risdate>2008</risdate><volume>53</volume><issue>4</issue><spage>416</spage><epage>425</epage><pages>416-425</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims: To describe three cases of purely in situ salivary duct carcinoma, so as better to define the entity.
Methods and results: Three primary tumours of the parotid gland are presented, in each case composed of cysts and ducts and lined by high nuclear grade epithelial cells. All parts of each tumour were surrounded by a myoepithelial cell rim and there was no evidence of invasion. The tumour cells expressed immunohistochemical markers seen in invasive salivary duct carcinoma of usual (high‐grade) type. In two cases the androgen receptor (AR) reaction was strong, but there was no immunohistochemical expression of HER2 protein or gene amplification by in situ hybridization. In the remaining case, fewer nuclei stained for AR, but both HER2 protein and gene amplification were demonstrated.
Conclusions: Salivary duct carcinoma in situ is morphologically similar to breast ductal carcinoma in situ and, although our cases are few, salivary duct carcinoma in situ can possibly be subdivided into luminal and non‐luminal cell types, as can analogous mammary neoplasms. The present study cannot determine whether low‐grade cribriform cystadenocarcinoma, architecturally similar but immunohistochemically different, is part of the spectrum of salivary duct carcinoma in situ, or whether it represents a separate entity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18983607</pmid><doi>10.1111/j.1365-2559.2008.03135.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adenocarcinoma - metabolism Adenocarcinoma - pathology Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Humans Immunohistochemistry In Situ Hybridization Investigative techniques, diagnostic techniques (general aspects) Medical sciences parotid gland Parotid Gland - pathology Parotid Neoplasms - metabolism Parotid Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptor, ErbB-2 - metabolism Receptors, Androgen - metabolism Salivary Ducts - pathology salivary gland neoplasms silver in situ hybridization |
title | Salivary duct carcinoma in situ of the parotid gland |
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