Efficacy of closantel plus albendazole liquid suspension against natural infection of gastrointestinal parasites in camels

• Published in: Veterinary parasitology 1999-03, Vol.82 (2), p.173-178
• Main Authors: Al-Qudah, K.M, Sharif, L.A, Al-Rawashdeh, O.F, Al-Ani, F.K
• Format: Article
• Language: English
• Subjects: ADMINISTRACION ORAL; ADMINISTRATION ORALE; Albendazole; Albendazole - administration & dosage; Albendazole - therapeutic use; Animals; ANTHELMINTHIQUE; ANTHELMINTICS; Anthelmintics - administration & dosage; Anthelmintics - therapeutic use; ANTIHELMINTICOS; APPAREIL DIGESTIF; ASCARIS; BENZIMIDAZOLE; BENZIMIDAZOLES; CAMELLO; CAMELS; Camelus - parasitology; CHAMEAU; Closantel; DIGESTIVE SYSTEM; Dromedary; Drug Combinations; FASCIOLA HEPATICA; Feces - parasitology; Female; HAEMONCHUS; Helminthiasis, Animal - drug therapy; Intestinal Diseases, Parasitic - drug therapy; Intestinal Diseases, Parasitic - veterinary; JORDAN; JORDANIA; JORDANIE; Male; ORAL ADMINISTRATION; Parasite Egg Count - veterinary; Pregnancy; Salicylanilides - administration & dosage; Salicylanilides - therapeutic use; SISTEMA DIGESTIVO; Suspensions
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/S0304-4017(99)00010-2

Oral administration of closantel in a dose of 10 mg/kg plus albendazole in a dose of 5 mg/kg liquid suspension was studied in 75 camels naturally infected with various types of gastrointestinal parasites. The camels involved were 15 pregnant she-camels, 20 non-pregnant she-camels and 40 male camels of various ages. Each camel received a single oral dose of closantel (10 mg/kg) plus albendazole (5 mg/kg) orally. Two weeks later, 20 camels of this group were re-dosed again with the same dose of the anthelmintic. Fecal samples were collected per rectum from all camels at the time of treatment and again 14 and 42 days post treatment. Fecal egg counts and generic determination of third stage larvae was performed. Results indicated that six different species of gastrointestinal tract parasites were identified in camels. Single treatment of closantel plus albendazole mixture reduced egg counts in camels by 100%, 100%, 98% and 77% for Haemonchus longistipes, Ascaris spp., Monezia expansa and Fasciola hepatica, respectively. However, administration of the drug twice on the base of 2 weeks apart significantly raised the efficacy of the drug for clearance of the parasites from 92.5% to 100% in camels infected with various parasites. Camels were not adversely affected by treatment.